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A team led by neurobiologist Prof. Dr. Hilmar Bading at Heidelberg University has identified a key molecular process that drives the progression of Alzheimer's disease. Working with researchers from Shandong University (China), the scientists used a mouse model of Alzheimer's to show that a harmful protein interaction causes brain cells to die, leading to cognitive decline. The findings point to new possibilities for developing more effective treatments. The harmful protein interaction involves two components previously studied: the NMDA receptor and the TRPM4 ion channel. NMDA receptors play an essential role in communication between nerve cells and are located on the cell surface, both at synapses and in areas outside these junctions. They are activated by glutamate, a key neurotransmitter. When NMDA receptors function within synapses, they support neuron survival and help maintain cognitive function. However, when TRPM4 interacts with NMDA receptors outside synap...
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Renal Function Test

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